Nutrasource Blog

GLP-1 Receptor Agonists: Reshaping Dietary Supplement Innovation

Posted by Dr. Stephanie-Anne Girard on Wed, Aug 13, 2025

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The weight loss category has evolved dramatically over the past few decades, from meal replacement shakes in the ‘90s to fat burners, keto aids, and now the GLP-1 effect. 

As GLP-1 drugs dominate headlines for their role in weight and appetite control, supplement developers are taking notice. Consumer interest in satiety, metabolic health, and glucose balance is surging which opens the door for functional ingredients to meet new demands. And this is just the beginning. 

In the ‘90s, weight loss supplements were all about meal replacement shakes. By the 2000s, it was thermogenics and stimulants such as caffeine, ephedra, green tea extract. Then came appetite suppressants, keto aids, and blood sugar support formulas. 

Now, we’re entering the GLP-1 era. 

The U.S. weight loss supplement market is projected to more than double by 2030, growing from $8.5M to $17.9M (source). Consumer expectations are shifting toward appetite control, satiety, and metabolic health - all influenced by the popularity of GLP-1 receptor agonist drugs. 

 

Unlike pharma, supplements must approach this trend strategically. As discussed in our webinar, brands can align with consumer interest without crossing regulatory lines. We’re seeing: 

  • Natural satiety ingredients like glucomannan and 5-HTP gain traction 
  • Interest in “GLP-1-like” botanicals like berberine and cinnamon 
  • A new market for products supporting GLP-1 drug users experiencing side effects like GI distress, nutrient gaps, and muscle loss 

 

Do you have a question we could help answer? Are you exploring clinical or regulatory considerations? Contact us today and a member of our team will be in touch with you.  

About the Author

Stephanie Anne-1

 

Stephanie-Anne Girard, PhD
Director, Scientific Affairs
Dr. Stéphanie-Anne Girard is the Director of Scientific Affairs at SGS Nutrasource, bringing over 15 years of expertise in clinical research across natural health products, dietary supplements, and pharmaceuticals. She oversees clinical trial design, data interpretation, and the development of high-quality scientific documents, collaborating with biostatistics, medical writing, and regulatory affairs teams to ensure scientific excellence. Dr. Girard holds a PhD in Nutritional Sciences with a focus on prebiotics and completed post-doctoral research in probiotics. An experienced author and international speaker, she has played a key role in promoting scientific rigor and supporting regulatory compliance, contributing to the success of client projects.

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